Both lysosomes and vacuoles are single membranous structures and both perform different types of functions. Lysosomes can hydrolyze all types of organic substances, except cellulose because it contains hydrolytic enzymes that work under acidic pH. They perform phagocytic functions and hence, are known as suicidal bags.
However, the vacuoles are non-cytoplasmic sacs covered by a membrane. It is found in animal and plant cells both that contain sap, water, excretory substances, etc. The membrane surrounding the vacuole is called tonoplast which is semi-permeable in nature. Vacuole separates harmful substances from cell cytoplasm and maintains osmotic pressure or turgidity. Some freshwater invertebrates like Amoeba, Paramecium, etc. contain contractile vacuoles. This contractile vacuole performs several functions like osmoregulation and excretion. The other type of vacuole is known as food vacuole. It stores the food while gas vacuoles store metabolic gases and take part in buoyancy regulation.