What is the significance of juxtaglomerular apparatus(JGA) in kidney function?

Asked by Pragya Singh | 1 year ago |  210

1 Answer

Solution :-

Juxtaglomerular apparatus (JGA) is formed by modifying the distal convoluted tubule and afferent arteriole. It is located where the afferent arteriole and the distal convoluted tubule (DLT) come in contact. It contains juxtaglomerular cells which are the specialized cells of the arteriole and also contain an enzyme that regulates blood pressure and this enzyme is called renin. Fall in glomerular filtration rate activates the juxtaglomerular cell which causes the release of renin. Renin stimulates the glomerular blood flow by which the glomerular filtration rate comes to normal. Angiotensin gets converted into Angiotensin I with the help of renin and further conversion into Angiotensin II takes place. Angiotensin II increases the glomerular filtration rate by an increase in glomerular blood pressure. It also releases aldosterone by activating the adrenal cortex. The mechanism of renin and angiotensin is known as the Renin-Angiotensin mechanism.

Answered by Abhisek | 1 year ago

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