General anesthesia is used for major operations to cure the patients and conduct pain free surgeries. Propofol is a commonly used anesthetic injected for major operations such as knee replacement or open heart surgery. It also acts as a sedative and an analgesic.
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A patient is rushed to operation theatre for a 2-hour cardiac surgery. A person is anesthetized when its blood stream contains at least 3 mg of propofol per kg of body weight. The rate of change of propofol(x), in the body is proportional to the quantity of propofol present at that time. Based on the above information. Answer the following questions:
(a) Show that propofol given intravenously is eliminated exponentially from the patients’ blood stream
(b) What dose of propofol should be injected to induce unconsciousness in a 50 Kg adult for a two hours operation?
(Given \( (2)^{\dfrac{2}{5}}\)=1.1487 & assume half-life of propofol = 5 hours)